An inhibitor of CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors); selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2

Cobicistat – 1 mg

Brand:
Cayman
CAS:
1004316-88-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cobicistat is an inhibitor of the cytochrome P450 (CYP) isomer CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors).{41224} It is selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19). Cobicistat does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM). Formulations containing cobicistat have been used to slow the metabolism of concomitantly administered protease inhibitors in the treatment of HIV.{41225}  

 

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SKU: 23433 - 1 mg Category:

Description

An inhibitor of CYP3A (IC50s = 30-285 nM for CYP3A metabolism of various HIV protease inhibitors); selective for CYP3A over other CYP isomers (IC50 = >25 μM for CYP1A2, 2C8, 2C9, and 2C19); does not inhibit HIV-1 protease (IC50 = >30 μM) or affect HIV replication in MT-2 cells (EC50 = >30 μM)

Formal name: (3R,6R,9S)-12-methyl-13-[2-(1-methylethyl)-4-thiazolyl]-9-[2-(4-morpholinyl)ethyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester

Synonyms:  GS-9350

Molecular weight: 776

CAS: 1004316-88-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Toxicology|Drug Metabolism|Cytochrome P450

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