A substituted quinoline with neuroprotective

CMS121 – 5 mg

Brand:
Cayman
CAS:
1353224-53-9
Storage:
-20
UN-No:
Non-Hazardous - /

CMS121 is a substituted quinoline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.{47397,47398,47400} It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay.{47397} CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively.{47398} It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nitric oxide synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.{47400}  

 

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SKU: 27085 - 5 mg Category:

Description

A substituted quinoline with neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities; maintains GSH levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a TEAC assay; protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro (EC50s = 7 and 200 nM, respectively); renoprotective in a SAMP8 mouse model of chronic kidney disease associated with rapid aging at 10 mg/kg per day starting at nine months of age

Formal name: 4-[4-(cyclopentyloxy)-2-quinolinyl]-1,2-benzenediol

Synonyms: 

Molecular weight: 321.4

CAS: 1353224-53-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Kidney & Renal Disease|Chronic Kidney Disease||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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