A prodrug form of the KCC2 activator CLP 257; increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats at 100 mg/kg; restores stepping ability

CLP 290 – 5 mg

Brand:
Cayman
CAS:
1181083-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

CLP 290 is a carbamate prodrug form of the K+/Cl- cotransporter 2 (KCC2) activator CLP 257 (Item No. 30948).{57069} It increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats when administered at a dose of 100 mg/kg.{57069,57072} CLP 290 (35 mg/kg) also restores stepping ability, as well as increases body weight support and stride length, in a mouse model of paralysis induced by staggered spinal lesions.{57226}  

 

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SKU: 31448 - 5 mg Category:

Description

A prodrug form of the KCC2 activator CLP 257; increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats at 100 mg/kg; restores stepping ability, as well as increases body weight support and stride length, in a mouse model of paralysis at 35 mg/kg

Formal name: 1-pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester

Synonyms: 

Molecular weight: 404.5

CAS: 1181083-81-7

Purity: ≥98%

Formulation: A crystalline solid

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