A metabolite of clozapine and muscarinic DREADD agonist (EC50s = 16.7

Clozapine N-oxide – 5 mg

Brand:
Cayman
CAS:
34233-69-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Clozapine-N-oxide is a major metabolite of clozapine (Item No. 12059) and an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively).{27576,35354} It prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors.{35354} Clozapine-N-oxide increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors.{42492}  

 

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Description

A metabolite of clozapine and muscarinic DREADD agonist (EC50s = 16.7, 323, 17.4, 18.3, and 18.7 nM for PASMCs expressing hM1-5D receptors, respectively); prevents action potential firing in cultured hippocampal neurons transiently expressing hM4D receptors; increases glutamate in the nucleus accumbens core and inhibits cue-induced reinstatement of cocaine-seeking behavior in rats transfected with hM3Dq DREADD receptors,

Formal name: 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Synonyms:  CNO

Molecular weight: 342.8

CAS: 34233-69-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|DREADD Research

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