An internal standard for the quantification of clozapine by GC- or LC-MS

Clozapine-d4 – 500 µg

Brand:
Cayman
CAS:
204395-52-8
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Clozapine-d4 is intended for use as an internal standard for the quantification of clozapine (Item Nos. 12059 | 25779) by GC- or LC-MS. Clozapine is a partial agonist at the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 180 nM).{22208,36950} It also binds to 5-HT2A, 5-HT2C, 5-HT3, 5-HT6 and 5-HT7 receptors (Kis = 3.3, 13, 110, 4, and 21 nM, respectively), as well as the histamine H1 and α1-adrenergic receptors (Kis = 2.1 and 23 nM, respectively). It does not bind to the 5-HT1B receptor and has a lower affinity for dopamine receptors (Kis = 540, 150, and 360 nM for D1-3, respectively). Clozapine induces the release of glutamate and D-serine, an agonist at the glycine site of the NMDA receptor, from astrocytes, and reduces the expression of astrocytic glutamate transporters.{22207} It reverses locomotor hyperactivity and deficits in prepulse inhibition of acoustic startle in a rat neonatal ventral hippocampal ibotenic lesion model of schizophrenia when administered at a dose of 2.5 mg/kg per day.{39941} Formulations containing clozapine have been used in the treatment of schizophrenia.  

 

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Description

An internal standard for the quantification of clozapine by GC- or LC-MS

Formal name: 8-chloro-11-(4-methyl-1-piperazinyl-d4)-5H-dibenzo[b,e][1,4]diazepine

Synonyms: 

Molecular weight: 330.9

CAS: 204395-52-8

Purity: ≥99% deuterated forms (d1-d4)

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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