A β-lactam antibiotic; active against clinical isolates of S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 µg/ml

Cloxacillin (sodium salt) – 25 g

Brand:
Cayman
CAS:
642-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin (Item No. 23954).{52188} It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 µg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 µg/ml for all).{52188,39101} Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 µg/ml, respectively).{52189} It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 µM, respectively).{39103} Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.{52190}  

 

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Description

A β-lactam antibiotic; active against clinical isolates of S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 µg/ml, respectively), but not 34 Gram-negative bacteria (MICs = >128 µg/ml for all); binds to S. aureus PBP1-4 (IC50s = 0.04-2.5 µg/ml); binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 µM, respectively); decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection

Formal name: (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt

Synonyms: 

Molecular weight: 457.9

CAS: 642-78-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Penicillins||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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