A tricyclic antidepressant that potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM

Clomipramine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
17321-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

Clomipramine is a tricyclic antidepressant, the 3-chlorinated derivative of imipramine (Item No. 15890).{25873} Like imipramine, clomipramine potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively).{25680,22877} It also is an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively).{25914}  

 

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Description

A tricyclic antidepressant that potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively); also an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2, respectively)

Formal name: 3-chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride

Synonyms: 

Molecular weight: 351.3

CAS: 17321-77-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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