A SERM that impairs the activation of ERs by 17β-estradiol; potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM

Clomiphene (citrate) – 5 g

Brand:
Cayman
CAS:
50-41-9
Storage:
-20
UN-No:
Non-Hazardous - /

Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}  

 

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Description

A SERM that impairs the activation of ERs by 17β-estradiol; potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively); enhances the release of gonadotropin-releasing hormone, culminating in ovulation

Formal name: 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-ethanamine 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Synonyms:  Clomifene|NSC 35770|Omifin

Molecular weight: 598.1

CAS: 50-41-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology

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