A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM

Clofarabine – 5 mg

Brand:
Cayman
CAS:
123318-82-1
Storage:
-20
UN-No:
Non-Hazardous - /

Clofarabine is a nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM).{22561} It induces apoptosis in primary chronic lymphocytic leukemia cells by directly altering mitochondrial transmembrane potential.{22560} Clofarabine demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.{22558,22559,22562}  

 

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Description

A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM) as well as various other leukemias and solid tumors

Formal name: 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Synonyms:  Clolar|Evoltra

Molecular weight: 303.7

CAS: 123318-82-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Nucleotides/Nucleosides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death|Apoptosis

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