A metal-chelating antimicrobial agent with neuroprotective properties; inhibits the growth of A. fumigatus (MIC values of 1

Clioquinol – 5 mg

Brand:
Cayman
CAS:
130-26-7
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}  

 

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SKU: 10021 - 5 mg Category:

Description

A metal-chelating antimicrobial agent with neuroprotective properties; inhibits the growth of A. fumigatus (MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively); decreases neuronal loss in the SNc and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson’s disease at 37 mg/kg; reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice,

Formal name: 5-chloro-7-iodo-8-quinolinol

Synonyms:  Iodochlorohydroxyquin|NSC 3531|NSC 74938

Molecular weight: 305.5

CAS: 130-26-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Metal Chelators||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Aspergillosis||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease||Research Area|Neuroscience|Neuroprotection

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