An active metabolite of clindamycin; formed via S-oxidation of clindamycin primarily by CYP3A4; inhibits the growth of P. prevotti

Clindamycin Sulfoxide – 500 µg

Brand:
Cayman
CAS:
22431-46-5
Storage:
-20
UN-No:
Non-Hazardous - /

Clindamycin sulfoxide is an active metabolite of the antibiotic clindamycin (Item No. 15006).{48218} It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.{48219}  

 

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Description

An active metabolite of clindamycin; formed via S-oxidation of clindamycin primarily by CYP3A4; inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro (MICs = 2, 2, and 1 mg/L, respectively)

Formal name: 7-chloro-1,6,7,8-tetradeoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-(methylsulfinyl)-L-threo-α-D-galacto-octopyranose

Synonyms:  U-25026A

Molecular weight: 441

CAS: 22431-46-5

Purity: ≥90% (mixture of diastereomers)

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Toxicology|Drug Metabolism

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