An adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes; inhibits lymphocyte growth with an IC50 value of 45 nM

Cladribine – 10 mg

Brand:
Cayman
CAS:
4291-63-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase.{21535,21539} It inhibits lymphocyte growth with an IC50 value of 45 nM.{21536} The pharmacokinetics of clabridine in humans have been published.{21537} After only a single course of treatment, clabridine eradicates hairy cell leukemia.{21541} It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.{21540,21538}  

 

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SKU: 12085 - 10 mg Category:

Description

An adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes; inhibits lymphocyte growth with an IC50 value of 45 nM

Formal name: 2-chloro-2′-deoxy-adenosine

Synonyms:  ​2-Chlorodeoxyadenosine|Biodribin|Jk 6251|Leustatin|NSC 105014|RWJ 26251

Molecular weight: 285.7

CAS: 4291-63-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Innate Immunity

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