An antibody-drug conjugate containing SN-38 and a maleimidocaproyl linker; binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM) when linked to hMN-14; increases survival in a colon carcinoma mouse model of lung metastasis when linked to hMN-14

CL2-SN-38 – 10 mg

Brand:
Cayman
CAS:
1036969-20-6
Storage:
-20
UN-No:
Non-Hazardous - /

CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 (Item No. 15632) and a maleimidocaproyl linker.{52050} CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis.  

 

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SKU: 28215 - 10 mg Category:

Description

An antibody-drug conjugate containing SN-38 and a maleimidocaproyl linker; binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM) when linked to hMN-14; increases survival in a colon carcinoma mouse model of lung metastasis when linked to hMN-14

Formal name: N-[32-[4-[[[[4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexyl]carbonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1,5-dioxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacont-1-yl]-L-phenylalanyl-N-[4-[[[[[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-4-yl]oxy]carbonyl]oxy]methyl]phenyl]-L-lysinamide

Synonyms: 

Molecular weight: 1,627.80

CAS: 1036969-20-6

Purity: ≥98%

Formulation: A crystalline solid

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