A pan PAD inhibitor (IC50s = 0.8

Cl-Amidine (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1373232-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

Cl-Amidine is an inhibitor of protein arginine deiminases (PAD; IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4 in vitro, respectively).{18132,19982} It irreversibly inactivates all four PAD subtypes (kinact/KI = 37,000, 1,200, 2,000, and 13,000 M-1min-1 for PAD1-4, respectively) by covalently modifying an active site cysteine that is important for its catalytic activity.{18132,36047} Cl-Amidine is cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05, and 1 μM, respectively).{18529} In a collagen-induced mouse model of inflammatory arthritis, Cl-amidine dose-dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.{19981}  

 

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SKU: 10599 - 5 mg Category:

Description

A pan PAD inhibitor (IC50s = 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively, in vitro); irreversibly inactivates PAD4 (kinact/KI = 13,000 M-1min-1) and PAD3 (kinact/KI = 2,000 M-1min-1); cytotoxic to HL-60, MCF-7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05, and 1 μM, respectively),

Formal name: N-[(1S)-1-(aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 347.2

CAS: 1373232-26-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deiminases||Research Area|Epigenetics, Transcription, & Translation|Writers|Citrullination||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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