A potent

CL 387,785 – 10 mg

Brand:
Cayman
CAS:
194423-06-8
Storage:
-20
UN-No:
Non-Hazardous - /

Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers.{14867} CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM).{31034} It blocks EGF-stimulated autophosphorylation of receptors in cells (IC50 = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM).{31034} CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.{31034}  

 

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Description

A potent, irreversible inhibitor of EGFR kinase activity (IC50 = 370 pM); halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC50s = 31-125 nM); profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days

Formal name: N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide

Synonyms:  EKB-785|EKI-785|WAY-EKI-785

Molecular weight: 381.2

CAS: 194423-06-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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