A β3-adrenoceptor agonist (EC50 = 3 nM) that is >10

CL 316,243 (sodium salt) – 500 µg

Brand:
Cayman
CAS:
138908-40-4
Storage:
-20
UN-No:
Non-Hazardous - /

CL 316,243 is a β3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over β1 and β2.{30564,25151} It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity.{20851,30565}  

 

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Description

A β3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over β1 and β2; causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity

Formal name: 5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid, disodium salt

Synonyms: 

Molecular weight: 465.8

CAS: 138908-40-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Endocrinology & Metabolism|Thermogenesis

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