An Arp2/3 inhibitor (IC50s = 4

CK-666 – 1 mg

Brand:
Cayman
CAS:
442633-00-3
Storage:
-20
UN-No:
Non-Hazardous - /

CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex (IC50s = 4, 17, and 5 μM for the human, bovine, and S. pombe complexes, respectively, in an actin polymerization assay).{27974} It binds at the Arp2/3 interface, stabilizing the inactive conformation of the complex.{53317} CK-666 (40 μM) inhibits actin comet tail formation around intracellular L. monocytogenes in infected SKOV3 cells.{27974} It induces actin remodeling, inhibits lamellipodia formation, and reduces the motility rate in M-1 epithelial cells when used at a concentration of 200 μM.{34274} CK-666 (100 μM) impairs long-term fear memory formation in rats when microinjected into the lateral amygdala.{53318}  

 

Available on backorder

Add to quotes
SKU: 29038 - 1 mg Category:

Description

An Arp2/3 inhibitor (IC50s = 4, 17, and 5 μM for the human, bovine, and S. pombe complexes, respectively, in an actin polymerization assay); binds at the Arp2/3 interface, stabilizing the inactive conformation of the complex; inhibits actin comet tail formation around intracellular L. monocytogenes in infected SKOV3 cells at 40 μM; induces actin remodeling, inhibits lamellipodia formation, and reduces the motility rate in M-1 epithelial cells at 200 μM; impairs long-term fear memory formation in rats when microinjected into the lateral amygdala at 100 μM

Formal name: 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide

Synonyms: 

Molecular weight: 296.3

CAS: 442633-00-3

Purity: ≥98%

Formulation: A crystalline solid

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 500 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 10 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 10 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page