A cardiac-specific myosin activator that promotes myosin cross-bridge formation

CK-1827452 – 5 mg

Brand:
Cayman
CAS:
873697-71-3
Storage:
-20
UN-No:
Non-Hazardous - /

CK-1827452 is a diaryl urea compound that increases cardiac myosin ATPase activity in a dose-dependent manner that is selective for cardiac myosin over non-cardiac myosins.{32877} It promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP.{32877} It has been shown to increase cardiac efficiency in clinical studies of patients with chronic heart failure.{32877}  

 

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Description

A cardiac-specific myosin activator that promotes myosin cross-bridge formation, increasing the duration and amount of myocyte contraction without affecting intracellular calcium or cAMP

Formal name: 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid, methyl ester

Synonyms: 

Molecular weight: 401.4

CAS: 873697-71-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators||Research Area|Cardiovascular System|Cardiovascular Diseases|Heart Failure||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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