Histone H3 is citrullinated by PAD4 at residues R2

Citrullinated Histone H3 (Clone 11D3) ELISA Kit – 96 wells

Brand:
Cayman
Storage:
-20

Histone H3 is citrullinated by peptidylarginine deiminase 4 (PAD4) at residues R2, R8, and R17 during the processes of epigenetic chromatin remodeling and neutrophil extracellular trap (NET) formation. In vitro, citrullinated H3 (CitH3) is released from neutrophils that have been stimulated with calcium ionophore during the process of NETosis, and can be freed from NETs by treatment with nuclease. The measurement of CitH3, either in cell lysates or released during NETosis can be used as a functional readout of pharmacological PAD inhibition.  

 

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SKU: 501620 - 96 wells Category:

Description

Histone H3 is citrullinated by PAD4 at residues R2, R8, and R17 during the processes of epigenetic chromatin remodeling and NET formation. In vitro, CitH3 is released from neutrophils that have been stimulated with calcium ionophore during the process of NETosis, and can be freed from NETs by treatment with nuclease. The measurement of CitH3, either in cell lysates or released during NETosis can be used as a functional readout of pharmacological PAD inhibition.

Formulation:

Formal name:

Synonyms:  CitH3 (Clone 11D3) EIA Kit

Host:

Imunogen:

Applications: 

Clone: 11D3

Purity:

Origin: Animal/Bovine|Animal/Mouse

Application|ELISA||Product Type|Assay Kits|ELISA||Research Area|Immunology & Inflammation|Innate Immunity|NETosis

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