Description
A coumarin with diverse biological activities; reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients; induces cell cycle arrest at the G1 phase and inhibits proliferation of A375, MCF-7, PC3, and SW620 cancer cells (IC50s = 250-325 µM); active against various Gram-positive and Gram-negative bacteria (MICs = 16-64 µg/ml); increases prothrombin time in isolated rat platelet-poor plasma; prevents decreases in locomotor activity and increases in hippocampal MAO-A levels in a rat model of chronic mild stress-induced depression
Formal name: 5,7-dimethoxy-2H-1-benzopyran-2-one
Synonyms: 5,7-Dimethoxycoumarin
Molecular weight: 206.2
CAS: 487-06-9
Purity: ≥95%
Formulation: A crystalline solid
