A coumarin with diverse biological activities; reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients; induces cell cycle arrest at the G1 phase and inhibits proliferation of A375

Citropten – 5 g

Brand:
Cayman
CAS:
487-06-9
Storage:
-20
UN-No:
Non-Hazardous - /

Citropten is a coumarin that has been found in bergamot extracts and has diverse biological activities.{48867,48868,48869,48870} It reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients.{48867} Citropten induces cell cycle arrest at the G1 phase and inhibits proliferation of A375, MCF-7, PC3, and SW620 cancer cells (IC50s = 250-325 µM).{48868} It is active against various Gram-positive and Gram-negative bacteria (MICs = 16-64 µg/ml).{48869} Citropten increases prothrombin time in isolated rat platelet-poor plasma. In vivo, citropten (10 mg/kg) prevents decreases in locomotor activity and increases in hippocampal monoamine oxidase A (MAO-A) levels in a rat model of chronic mild stress-induced depression.{48870}  

 

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SKU: 29338 - 5 g Category:

Description

A coumarin with diverse biological activities; reduces IL-8 mRNA accumulation induced by TNF-α or heat-inactivated P. aeruginosa in IB3-1 cells derived from cystic fibrosis patients; induces cell cycle arrest at the G1 phase and inhibits proliferation of A375, MCF-7, PC3, and SW620 cancer cells (IC50s = 250-325 µM); active against various Gram-positive and Gram-negative bacteria (MICs = 16-64 µg/ml); increases prothrombin time in isolated rat platelet-poor plasma; prevents decreases in locomotor activity and increases in hippocampal MAO-A levels in a rat model of chronic mild stress-induced depression

Formal name: 5,7-dimethoxy-2H-1-benzopyran-2-one

Synonyms:  5,7-Dimethoxycoumarin

Molecular weight: 206.2

CAS: 487-06-9

Purity: ≥95%

Formulation: A crystalline solid

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