A mycotoxin that inhibits the mitochondrial ATP synthetase system; inhibits soluble ATPase (KD = 4.1 µM)

Citreoviridin – 1 mg

Brand:
Cayman
CAS:
25425-12-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Citreoviridin is a mycotoxin isolated from several Penicillium species that has been shown to inhibit the mitochondrial ATP synthetase system.{26689,26688} It inhibits soluble ATPase (KD = 4.1 µM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.15 µM), and ATP-driven reduction of NAD+ by succinate (KD = 2 µM).{26689} Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.{26690}  

 

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SKU: 11319 - 1 mg Category:

Description

A mycotoxin that inhibits the mitochondrial ATP synthetase system; inhibits soluble ATPase (KD = 4.1 µM), ADP-stimulated respiration in isolated rat liver mitochondria (KD = 0.15 µM), and ATP-driven reduction of NAD+ by succinate (KD = 2 µM)

Formal name: 2,5-anhydro-1,6-dideoxy-2-C-[(8-(4-methoxy-5-methyl-2-oxo-2H-pyran-6-yl)-2-methyl-1E,3E,5E,7E-octatetraen-1-yl]-4-C-methyl-D-iditol

Synonyms: 

Molecular weight: 402.5

CAS: 25425-12-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|ATPases||Product Type|Biochemicals|Toxins|Mycotoxins||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Metabolism||Research Area|Cell Biology|Mitochondrial Biology

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