A selective serotonin reuptake inhibitor (IC50 = 1.8 nM for 5-HT reuptake in rat brain synaptosomes); selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM); potentiates 5-hydroxy-L-tryptophan-induced headweaving and tremor in mice (ED50s = 0.61 and 0.66 mmol/kg

Citalopram (hydrobromide) – 1 g

Brand:
Cayman
CAS:
59729-32-7
Storage:
-20
UN-No:
Non-Hazardous - /

Citalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with an IC50 value of 1.8 nM for 5-HT reuptake in rat brain synaptosomes.{38122} It is selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM). Citalopram potentiates headweaving and tremor induced by 5-hydroxy-L-tryptophan (Item No. 20539) in mice (ED50s = 0.61 and 0.66 mmol/kg, respectively). It also acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM).{23021} Formulations containing citalopram have been used to treat depression. This product is also available as an analytical reference standard (Item No. 23252).  

 

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Description

A selective serotonin reuptake inhibitor (IC50 = 1.8 nM for 5-HT reuptake in rat brain synaptosomes); selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM); potentiates 5-hydroxy-L-tryptophan-induced headweaving and tremor in mice (ED50s = 0.61 and 0.66 mmol/kg, respectively); acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM)

Formal name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, monohydrobromide

Synonyms:  Bonitrile|Lu 10-171B|Nitalapram|Prepram

Molecular weight: 405.3

CAS: 59729-32-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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