A typical antipsychotic; dopamine D2 receptor antagonist (Ki = 0.38 nM); 5-HT2A inverse agonist (Ki = 7 nM); reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine in rats at 0.5 mg/kg; inhibits acid sphingomyelinase activity by 81.8% at 10 mM

cis-Flupenthixol (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
51529-01-2
Storage:
-20
UN-No:
Non-Hazardous - /

cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist (Ki = 0.38 nM), and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 7 nM).{26444} In vivo, cis-flupenthixol (0.5 mg/kg, i.p.) reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine without affecting development of conditioned place aversions in rats.{42313} cis-Flupenthixol also inhibits acid sphingomyelinase activity by 81.8% when used at a concentration of 10 mM.{26583}  

 

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Description

A typical antipsychotic; dopamine D2 receptor antagonist (Ki = 0.38 nM); 5-HT2A inverse agonist (Ki = 7 nM); reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine in rats at 0.5 mg/kg; inhibits acid sphingomyelinase activity by 81.8% at 10 mM

Formal name: 4-[3-[(3Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol, dihydrochloride

Synonyms:  cis-Flupentixol

Molecular weight: 507.4

CAS: 51529-01-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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