cis-10-Nonadecenoic acid is a C19:1 monounsaturated fatty acid. It has been examined for potential antitumor activity and was reported to inhibit HL-60 cell proliferation with an IC50 value of 295 µM and to prevent LPS-induced tumor necrosis factor production from mouse macrophages.{31488} Furthermore, long-chain fatty acids, such as cis-10-nonadecenoic acid, have been shown to inhibit p53 activity.{31533}
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A monounsaturated long chain fatty acid with potential antitumor and p53 inhibitory activity
Formal name: 10Z-nonadecenoic acid
Synonyms: Nonadeca-10(Z)-enoic Acid
Molecular weight: 296.5
CAS: 73033-09-7
Purity: ≥98%
Formulation: A solution in ethanol
Product Type|Biochemicals|Lipids|Fatty Acids||Research Area|Cancer||Research Area|Lipid Biochemistry|Fatty Acids
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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