A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors; enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine

CIQ – 5 mg

Brand:
Cayman
CAS:
486427-17-2
Storage:
-20
UN-No:
De Minimis - 3077 / 6.1

CIQ is a substituted tetrahydroisoquinoline that acts as a subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.{32554} It is without effect at subunits NR2A, NR2B, or glutamate receptors. CIQ enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine.{32554} It is a positive allosteric modulator that does not alter agonist EC50 values.{32553,32552}  

 

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Description

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors; enhances receptor responses two-fold (EC50 = 3 µM) by increasing channel opening frequency for glutamate or glycine

Formal name: (3-chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone

Synonyms: 

Molecular weight: 467.9

CAS: 486427-17-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience

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