An internal standard for the quantification of ciprofloxacin by GC- or LC-MS

Ciprofloxacin-d8 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
1216659-54-9
Storage:
-20
UN-No:
Non-Hazardous - /

Ciprofloxacin-d8 is intended for use as an internal standard for the quantification of ciprofloxacin (Item No. 14286) by GC- or LC-MS. Ciprofloxacin is a fluoroquinolone antibiotic.{22833} It is active against a variety of Gram-positive and Gram-negative bacteria in vitro, including S. aureus, L. monocytogenes, P. aeruginosa, Legionella, N. gonorrhoeae, and H. pylori (MIC50s = 0.004-1 µg/ml).{32846} It is also active against clinical isolates of Bacteroides, Fusobacterium, Eubacterium, Actinomyces, Peptococcus, Peptostreptococcus, and Streptococcus in vitro (MIC50s = 0.5-2 µg/ml).{32013} Ciprofloxacin inhibits S. aureus DNA gyrase and topoisomerase IV (IC50s = 13.5 and 5.76 µg/ml, respectively).{27493} It reduces mortality in mouse models of intraperitoneal E. coli, P. vulgaris, K. pneumoniae, P. aeruginosa, and S. aureus infection (ED90-100s = 1-5, 2.5-5, 5-10, 20-40, and 80 mg/kg, respectively) and prevents mortality in a mouse model of subcutaneous S. typhimurium infection at 10 mg/kg.{39939,39940} Formulations containing ciprofloxacin have been used in the treatment of bacterial infections.  

 

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SKU: 25466 - 5 mg Category:

Description

An internal standard for the quantification of ciprofloxacin by GC- or LC-MS

Formal name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-1,4-dihydroquinoline-3-carboxylic acid, monohydrochloride

Synonyms: 

Molecular weight: 375.9

CAS: 1216659-54-9

Purity: ≥99% deuterated forms (d1-d8)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antibiotics|Quinolones & Fluoroquinolones||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|STDs

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