An allosteric agonist of the CaSR (EC50 = 79.4 nM in HEK293T cells expressing the human receptor); decreases plasma levels of PTH in rats from 0.1-10 mg/kg; decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism

Cinacalcet (hydrochloride) – 25 mg

Brand:
Cayman
CAS:
364782-34-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor (CaSR; EC50 = 79.4 nM in HEK293T cells expressing the human receptor).{26279} In vivo, cinacalcet (0.1-10 mg/kg, s.c.) decreases plasma levels of parathyroid hormone (PTH) in rats. It also decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism.{39827} Formulations containing cinacalcet have been used in the treatment of secondary hyperparathyroidism due to end-stage renal disease and hypercalcemia in patients with parathyroid carcinoma.  

 

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Description

An allosteric agonist of the CaSR (EC50 = 79.4 nM in HEK293T cells expressing the human receptor); decreases plasma levels of PTH in rats from 0.1-10 mg/kg; decreases plasma levels of PTH and parathyroid cell proliferation in a mouse model of primary hyperparathyroidism,

Formal name: αR-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride

Synonyms:  AMG 073|KRN 1493|Mimpara

Molecular weight: 393.9

CAS: 364782-34-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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