A dihydropyridine L- and N-type calcium channel blocker; blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons at 10 μM; reduces the pressor response to acute cold stress

Cilnidipine – 1 g

Brand:
Cayman
CAS:
132203-70-4
Storage:
-20
UN-No:
Non-Hazardous - /

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM.{45100} Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats.{45101} It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg.{45102} Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.  

 

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SKU: 26080 - 1 g Category:

Description

A dihydropyridine L- and N-type calcium channel blocker; blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons at 10 μM; reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats at 3 mg/kg; reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at 3-100 μg/kg; reduces cerebral infarction area in a rat model of focal brain ischemia at 100 μg/kg

Formal name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl) 5-[(2E)-3-phenyl-2-propen-1-yl] ester

Synonyms:  FRC 8653

Molecular weight: 492.5

CAS: 132203-70-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Stroke||Research Area|Neuroscience|Neuroprotection|Ischemia

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