A hedgehog pathway inhibitor that blocks Shh-induced hedgehog pathway activation (IC50 = 7 µM); inhibits primary cilia formation; inhibits dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic AAA+ family; inhibits mTORC1 activity in uninfected and HCMV-infected cells

Ciliobrevin A – 25 mg

Brand:
Cayman
CAS:
302803-72-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 µM).{21061} It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.{34791}  

 

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Description

A hedgehog pathway inhibitor that blocks Shh-induced hedgehog pathway activation (IC50 = 7 µM); inhibits primary cilia formation; inhibits dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic AAA+ family; inhibits mTORC1 activity in uninfected and HCMV-infected cells

Formal name: 2,4-dichloro-α-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-benzenepropanenitrile

Synonyms:  HPI-4

Molecular weight: 358.2

CAS: 302803-72-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area

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