An integrin αVβ3 receptor antagonist; inhibits adhesion and induces apoptosis of U87MG and U373MG

Cilengitide – 25 mg

Brand:
Cayman
CAS:
188968-51-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide and integrin αVβ3 receptor antagonist.{39378} It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG) cells, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml. Cilengitide (200 μg/animal per day) delays tumor implantation time, reduces tumor growth, and prolongs survival in a U87MG mouse model of glioblastoma.{39379} Formulations containing cilengitide are under clinical investigation for the treatment of malignant glioma and melanomas.  

 

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Description

An integrin αVβ3 receptor antagonist; inhibits adhesion and induces apoptosis of U87MG and U373MG, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml; delays tumor implantation time, reduces tumor growth, and prolongs survival in a U87MG mouse model of glioblastoma when administered at a dose of 200 μg/animal per day

Formal name: cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl)

Synonyms:  EMD 121974

Molecular weight: 588.7

CAS: 188968-51-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis

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