Description
An inhibitor of dipeptidase (dehydropeptidase I); inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM); protects primary porcine renal proximal tubular epithelial cells from vancomycin-induced nephrotoxicity and apoptosis (200 μg/ml); protects mice from systemic infection by S. aureus, E. coli, and P. aeruginosa when administered in combination with imipenem; inhibits renal metabolism of imipenem to prolong its half-life
Formal name: (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
Synonyms:
Molecular weight: 358.5
CAS: 82009-34-5
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases
