An acyclic nucleoside phosphonate that is active against many different viruses including herpesvirus CMV; selectively inhibits CMV replication and CMV DNA synthesis (IC50 = 0.1 μM)

Cidofovir – 25 mg

Brand:
Cayman
CAS:
113852-37-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cidofovir is an acyclic nucleoside phosphonate that is active against herpesvirus (including cytomegalovirus (CMV)), polyomavirus, papillomavirus, adenovirus, and poxvirus infections. In vitro, cidofovir is converted to cidofovir diphosphate which incorporates into viral DNA, selectively inhibiting CMV replication and CMV DNA synthesis with IC50 values of 0.1 μM.{22167} Cidofovir has significantly long-lasting antiviral action because of the long half-life of its metabolites whose cellular uptake is slow due to the presence of the negatively charged phosphonate group.{22169} The antiviral efficacy of cidofovir has been demonstrated in numerous experimental animal model infections that mirror all major DNA virus infections in humans.{22168} It has also demonstrated remarkable activity as an antitumor agent in a variety of animal models of tumor growth.{22168}  

 

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Description

An acyclic nucleoside phosphonate that is active against many different viruses including herpesvirus CMV; selectively inhibits CMV replication and CMV DNA synthesis (IC50 = 0.1 μM)

Formal name: P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid

Synonyms:  GS-0504|HPMPC|Vistide

Molecular weight: 279.2

CAS: 113852-37-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Nucleotides/Nucleosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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