A reversible

CID-2745687 – 25 mg

Brand:
Cayman
CAS:
264233-05-8
Storage:
-20
UN-No:
Non-Hazardous - /

GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}  

 

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SKU: 12046 - 25 mg Category:

Description

A reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki of 12.8 nM; less potently blocks activation of GPR35 by zaprinast (IC50 = 160 nM); shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM)

Formal name: 1-(2,4-difluorophenyl)-5-[[2-[[(1,1-dimethylethyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid, methyl ester

Synonyms:  ML-194

Molecular weight: 395.4

CAS: 264233-05-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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