A prodrug form of desisobutyryl-ciclesonide; binds to the glucocorticoid receptor (Ki = 37 nM); selective for the glucocorticoid receptor over the estrogen

Ciclesonide – 1 mg

Brand:
Cayman
CAS:
126544-47-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.  

 

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Description

A prodrug form of desisobutyryl-ciclesonide; binds to the glucocorticoid receptor (Ki = 37 nM); selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors; inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation

Formal name: 16α,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11β-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione

Synonyms:  CIC|RPR 251526

Molecular weight: 540.7

CAS: 126544-47-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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