An inhibitor of class I HDACs with IC50 values of 0.9

CI-994 – 10 mg

Brand:
Cayman
CAS:
112522-64-2
Storage:
-20
UN-No:
Non-Hazardous - /

CI-994 is an inhibitor of class I HDACs displaying IC50 values of 0.9, 0.9, 1.2, and >20 μM when screened in vitro against recombinant human HDAC 1, 2, 3, and 8, respectively.{21578} CI-994 has a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents, in preclinical models both in vitro and in vivo and has advanced through phase I and II clinical trials in combination therapy treatments.{21576,21577,21579}  

 

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SKU: 12084 - 10 mg Category:

Description

An inhibitor of class I HDACs with IC50 values of 0.9, 0.9, 1.2, and >20 μM for recombinant human HDAC 1, 2, 3, and 8, respectively; displays a wide spectrum of antitumor activity, particularly in tumors normally refractory to conventional anticancer agents

Formal name: 4-(acetylamino)-N-(2-aminophenyl)-benzamide

Synonyms:  Goe 5549|N-Acetyldinaline|PD 123654|Tacedinaline

Molecular weight: 269.3

CAS: 112522-64-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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