An antibiotic isolated from a strain of Streptomyces; suppresses the growth of transplantable tumors in mice

Chrysomycin B – 250 µg

Brand:
Cayman
CAS:
83852-56-6
Storage:
-20
UN-No:
Non-Hazardous - /

Chrysomycin B is an antibiotic isolated from a strain of Streptomyces.{22201} It differs from its analog chrysomycin A (Item No. 14188){22203,22199} by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA.{22199,22204,22198} It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II.{22198} Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.{22200}  

 

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Description

An antibiotic isolated from a strain of Streptomyces; suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA; causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II

Formal name: 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one

Synonyms:  Albacarcin M|Virenomycin M

Molecular weight: 496.5

CAS: 83852-56-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation

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