Description
An antibacterial and anticancer aureolic acid; inhibits the growth of B. subtilis in an agar diffusion assay; inhibits the growth of SGC7901, HepG2, A549, HCT116, and COC1 cells, as well as HUVECs (IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respectively); halts the cell cycle in the G0/G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M cells at 30 nM; increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 in SCC-11 cells and reduces cell viability to 50% at 30 nM,
Formal name: (1S)-1-C-[(2S,3S)-7-[[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy]-3-[[O-2,6-dideoxy-3-C-methyl-4-O-(2-methyl-1-oxopropyl)-α-L-arabino-hexopyranosyl(1→3)-O-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4-tetrahydro-5,10-dihydroxy-6-methyl-4-oxo-2-anthracenyl]-5-deoxy-1-O-methyl-D-threo-2-pentulose
Synonyms: Aburamycin A|CMA2|NSC 131187
Molecular weight: 1,211.30
CAS: 6992-70-7
Purity: ≥98%
Formulation: A powder
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Autophagy||Research Area|Cancer|Cell Cycle|G1||Research Area|Cell Biology|Cell Cycle||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy
