An IKs and ICTFR blocker (IC50s = 6.89 and 19 μM in Xenopus oocytes expressing rat IKs and CTFR

Chromanol 293B – 10 mg

Brand:
Cayman
CAS:
163163-23-3
Storage:
-20
UN-No:
Non-Hazardous - /

Chromanol 293B is a blocker of slowly activating delayed-rectifier K+ current (IKs) with an IC50 value of 6.89 μM in Xenopus oocytes expressing rat IKs channels.{38238} It is selective, having no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM. Chromanol 293B increases the rate and extent of IKs in guinea pig ventricular cells in a dose-dependent manner.{38239} It also inhibits cystic fibrosis transmembrane conductance regulator (CTFR) Cl- currents (ICTFR) with an IC50 value of 19 μM in Xenopus oocytes expressing human CTFR.{38240}  

 

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Description

An IKs and ICTFR blocker (IC50s = 6.89 and 19 μM in Xenopus oocytes expressing rat IKs and CTFR, respectively); has no activity at rat Kv1.1 or Kir2.1 channels at a concentration of 30 μM; increases the rate and extent of IKs currents in guinea pig ventricular cells in a dose-dependent manner,

Formal name: rel-N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

Synonyms:  Chromanol 239B

Molecular weight: 324.4

CAS: 163163-23-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart

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