A cholesterol ester; a component of LDL; oxidiation of the arachidonate moiety contributes contributes to macrophage activation and foam cell formation in atherosclerosis; undergoes hydrolysis to release arachidonic acid during ACTH-stimulated prostaglandin synthesis in rat adrenocortical cells; levels increased in BLAF in pediatric cycstic fibrosis patients and placentas of women with chorioamnionitis

Cholesteryl Arachidonate – 10 mg

Brand:
Cayman
CAS:
604-34-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cholesteryl arachidonate is a cholesterol ester that is found in plasma and the adrenal gland.{42068} It is a component of low-density lipoprotein (LDL) and oxidiation of the arachidonate moiety contributes to macrophage activation and foam cell formation in atherosclerosis.{42069} Cholesteryl arachidonate undergoes hydrolysis to release arachidonic acid during ACTH-stimulated prostaglandin synthesis in rat adrenocortical cells.{42070} Levels of cholesteryl arachidonate are increased in the bronchoalveolar lavage fluid (BALF) in pediatric cystic fibrosis patients compared to healthy controls as well as in placentas of women with chorioamnionitis.{42071,42072}  

 

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Description

A cholesterol ester; a component of LDL; oxidiation of the arachidonate moiety contributes contributes to macrophage activation and foam cell formation in atherosclerosis; undergoes hydrolysis to release arachidonic acid during ACTH-stimulated prostaglandin synthesis in rat adrenocortical cells; levels increased in BLAF in pediatric cycstic fibrosis patients and placentas of women with chorioamnionitis

Formal name: (3β)-cholest-5-en-3-ol 3-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoate]

Synonyms:  20:4 Cholesteryl ester|Arachidonic Acid cholesteryl ester|Cholesterol 5Z,8Z,11Z,14-Z-Eicosatetraenoic Acid ester|Cholesterol Arachidonate

Molecular weight: 673.1

CAS: 604-34-2

Purity: ≥98%

Formulation: A neat oil

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Sterol Lipids

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