A cholesterol metabolite and intermediate in the biosynthesis of chenodeoxycholic acid; induces apoptosis in cornea and lens epithelial cells at 10 µg/ml in vitro; increases serum and liver cholestanol levels and leads to corneal opacities and gallstones in mice following dietary administration at 1%; leads to cholestanol deposition in the cerebellum in rats following dietary administration at 1%; levels are increased in plasma of patients with CTX

Cholestanol – 25 g

Brand:
Cayman
CAS:
80-97-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cholestanol is a cholesterol metabolite formed by oxidation and an intermediate in the biosynthesis of chenodeoxycholic acid (Item No. 10011286).{47049} Cholestanol (10 µg/ml) induces apoptosis in cornea and lens epithelial cells and increases the activity of IL-1β converting enzyme (ICE) and CPP32 proteases.{47050} Dietary administration of 1% cholestanol to mice increases serum and liver cholestanol levels and leads to corneal opacities and gallstones and in rats it leads to cholestanol deposition in the cerebellum.{47051} Cholestanol levels are increased in plasma of patients with cerebrotendinous xanthomatosis (CTX), a disease characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.{47052}  

 

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SKU: 9003101 - 25 g Category:

Description

A cholesterol metabolite and intermediate in the biosynthesis of chenodeoxycholic acid; induces apoptosis in cornea and lens epithelial cells at 10 µg/ml in vitro; increases serum and liver cholestanol levels and leads to corneal opacities and gallstones in mice following dietary administration at 1%; leads to cholestanol deposition in the cerebellum in rats following dietary administration at 1%; levels are increased in plasma of patients with CTX

Formal name: (5α)-cholestan-3β-ol

Synonyms:  (+)-Dihydrocholesterol|NSC 18188|β-Cholestanol

Molecular weight: 388.7

CAS: 80-97-7

Purity: ≥95%

Formulation: A solid

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