An inhibitor of tubulin polymerization (IC50 = 0.68 µM); inhibits chochicine tubulin binding at 5 µM; inhibits the growth of K562

CHM-1 – 1 mg

Brand:
Cayman
CAS:
154554-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

CHM-1 is an inhibitor of tubulin polymerization (IC50 = 0.68 µM) with anticancer activity.{57149} It inhibits colchicine (Item No. 9000760) tubulin binding by 39% when used at a concentration of 5 µM. CHM-1 inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM). It induces apoptosis in HA22T hepatocellular carcinoma cells in a concentration-dependent manner.{57150} CHM-1 (10 mg/kg) reduces tumor volume and increases survival in an HA22T mouse xenograft model.  

 

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SKU: 27647 - 1 mg Category:

Description

An inhibitor of tubulin polymerization (IC50 = 0.68 µM); inhibits chochicine tubulin binding at 5 µM; inhibits the growth of K562, NCI H226, HCT116, OVCAR-3, RXF 393L, SK-MEL-5, SF-268, and SF-295 cancer cells (mean GI50 = 130 nM); induces apoptosis in HA22T hepatocellular carcinoma cells; reduces tumor volume and increases survival in an HA22T mouse xenograft model at 10 mg/kg

Formal name: 6-(2-fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one

Synonyms:  NSC 656158

Molecular weight: 283.3

CAS: 154554-41-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Microtubule Dynamics||Research Area|Cancer|Cell Death|Apoptosis

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