A centrally acting muscle relaxant; activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1

Chlorzoxazone – 100 g

Brand:
Cayman
CAS:
95-25-0
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorzoxazone is a centrally acting muscle relaxant and activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively).{27789,23031} In vivo, chlorzoxazone (10 mg/kg) decreases alcohol but not water intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol.{43334} Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm. This product is also available as an analytical reference standard (Item No. 25826).  

 

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Description

A centrally acting muscle relaxant; activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively); decreases alcohol but not water intake in a dose dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent access to alcohol at 10 mg/kg

Formal name: 5-chloro-2(3H)-benzoxazolone

Synonyms:  NSC 26189

Molecular weight: 169.6

CAS: 95-25-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research||Research Area|Neuroscience|Pain Research

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