A potential impurity in commercial chlorthalidone preparations; has moderate antihypertensive activity

Chlorthalidone Impurity G – 1 mg

Brand:
Cayman
CAS:
16289-13-7
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects.{41079} Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output.{41853} It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity.{23242} Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy induced by deoxycorticosterone acetate (DOCA) in salt-hypertensive rats.{41854} Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.  

 

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Description

A potential impurity in commercial chlorthalidone preparations; has moderate antihypertensive activity

Formal name: 3-(3,4-dichlorophenyl)-2,3-dihydro-3-hydroxy-1H-isoindol-1-one

Synonyms: 

Molecular weight: 294.1

CAS: 16289-13-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Pharmaceutical Impurities||Product Type|Biochemicals|Small Molecule Inhibitors||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Kidney & Renal Disease

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