A non-thiazide diuretic; inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney; inhibits carbonic anhydrase isoforms CAVB

Chlorthalidone – 25 mg

Brand:
Cayman
CAS:
77-36-1
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output.{41853} It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM), which may mediate its sustained vasodilatory activity.{23242} Dietary administration of chlorthalidone (8 mg per animal per day) reduces arterial hypertension and prevents or reduces ventricular hypertrophy induced by deoxycorticosterone acetate (DOCA) in salt-hypertensive rats.{41854} Formulations containing chlorthalidone have been used alone or in combination with other antihypertensive agents to lower arterial blood pressure and as adjuvants to address edema caused by cardiac or renal disorders.  

 

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Description

A non-thiazide diuretic; inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney; inhibits carbonic anhydrase isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) and, to a lesser extent, CAI, CAII, IV, VA, and VI (Kis = 138-1,347 nM); reduces arterial hypertension and prevents or reduces DOCA-induced ventricular hypertrophy in salt-hypertensive rats

Formal name: 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide

Synonyms:  Hygroton|NSC 69200|Oradil|Thalitone®

Molecular weight: 338.8

CAS: 77-36-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy

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