A broad-spectrum tetracycline antibiotic; inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes

Chlortetracycline – 5 mg

Brand:
Cayman
CAS:
57-62-5
Storage:
-20
UN-No:
Non-Hazardous - /

Chlortetracycline is a broad-spectrum antibiotic originally isolated from S. aureofaciens.{36361,36363} It inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Haemophilus, Neisseria, Salmonella, and Staphylococcus.{36363} Chlortetracycline protects mice from infection by various strains of S. aureus with protective doses (PD50s) of 0.2-7.5 mg/kg, and from infection by E. coli (PD50 = 3 mg/kg) and K. pneumoniae (PD50 = 75 mg/kg).{36362} It acts by inhibiting protein synthesis, and it binds to a single site on the 30S ribosome subunit.{36361} Chlortetracycline is an ionophore and is selective for calcium over sodium, potassium, magnesium, strontium, and barium.{36364} It transports calcium from an aqueous phase into an organic phase environment or into multilamellar vesicles. Chlortetracycline is also a fluorescent dye that can be used to monitor calcium flux.{36365}  

 

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SKU: 23302 - 5 mg Category:

Description

A broad-spectrum tetracycline antibiotic; inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Hemophilus, Neisseria, Salmonella, and Staphylococcus; protects mice from infection by S. aureus (PD50s = 0.2-7.5 mg/kg for various strains), E. coli (PD50 = 3 mg/kg), and K. pneumoniae (PD50 = 75 mg/kg); an ionophore that is selective for calcium over sodium, potassium, magnesium, strontium, and barium

Formal name: (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Synonyms:  7-Chlortetracycline

Molecular weight: 478.9

CAS: 57-62-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Tetracyclines||Product Type|Biochemicals|Labeling & Detection|Dyes, Stains, & Indicators||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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