A dopamine D2 receptor antagonist that can block a subset of GABAA receptors in rat cortex that is also blocked by clozapine; effective against P. falciparum growth (EC50 = 1.7 µM)

Chlorprothixene (hydrochloride) – 25 g

Brand:
Cayman
CAS:
6469-93-8
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Chlorprothixene is a thioxanthine antipsychotic that functions by antagonizing dopamine D2 receptors.{32656} It can block a subset of GABAA receptors in rat cortex that is also blocked by clozapine (Item No. 12059).{32657} It has also been shown to be effective against P. falciparum growth with an EC50 value of 1.7 µM.{29940}  

 

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Description

A dopamine D2 receptor antagonist that can block a subset of GABAA receptors in rat cortex that is also blocked by clozapine; effective against P. falciparum growth (EC50 = 1.7 µM)

Formal name: (3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride

Synonyms:  cis-Chlorprothixene|NSC 169899

Molecular weight: 352.3

CAS: 6469-93-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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