A first generation sulfonylurea; increases glycolysis and inhibits glucagon-induced gluconeogenesis in isolated rat hepatocytes at 0.2 mM; reverses increases in blood glucose levels induced by hydrochlorothiazide and previous insulin in a rabbit model of diabetes at 250 mg/kg once or 10 mg/kg per day for six days

Chlorpropamide – 250 g

Brand:
Cayman
CAS:
94-20-2
Storage:
4
UN-No:
Non-Hazardous - /

Chlorpropamide is a first generation sulfonylurea.{48076} It increases glycolysis by increasing fructose-2,6-bisphosphate levels and inhibits glucagon-induced gluconeogenesis by augmenting the effect of insulin in isolated rat hepatocytes when used at a concentration of 0.2 mM. Chlorpropamide reverses increases in blood glucose levels induced by hydrochlorothiazide (Item No. 21304) and previous insulin in a rabbit model of diabetes when administered in a single 250 mg/kg dose or repeated doses of 10 mg/kg per day for six days.{48077} Formulations containing chlorpropamide have been used as adjuncts to diet and exercise in the treatment of type 2 diabetes.  

 

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SKU: 26087 - 250 g Category:

Description

A first generation sulfonylurea; increases glycolysis and inhibits glucagon-induced gluconeogenesis in isolated rat hepatocytes at 0.2 mM; reverses increases in blood glucose levels induced by hydrochlorothiazide and previous insulin in a rabbit model of diabetes at 250 mg/kg once or 10 mg/kg per day for six days

Formal name: 4-chloro-N-[(propylamino)carbonyl]-benzenesulfonamide

Synonyms:  NSC 44634|NSC 626720

Molecular weight: 276.7

CAS: 94-20-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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