A typical antipsychotic; an antagonist of dopamine D2

Chlorpromazine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
69-09-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM).{23093,24252} It is also an antagonist of histamine H1, α1a-, α2b-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively).{24253} CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats.{43329} CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Item No. 13119) in dogs.{43330}  

 

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Description

A typical antipsychotic; an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as 5-HT2A receptors (Ki = 1.8 nM); an antagonist of histamine H1, α1a-, α2b-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively); increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats at 10 mg/kg; reduces cisplatin-induced emesis in dogs at 0.3, 1, and 3 mg/kg

Formal name: 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, monohydrochloride

Synonyms:  CPZ

Molecular weight: 355.3

CAS: 69-09-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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