An internal standard for the quantification of chlorpromazine by GC- or LC-MS

Chlorpromazine-d6 (hydrochloride) – 500 µg

Brand:
Cayman
CAS:
1228182-46-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Chlorpromazine-d6 (CPZ-d6) is intended for use as an internal standard for the quantification of CPZ (Item No. 16129) by GC- or LC-MS. CPZ is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors (Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 1.8 nM).{23093,24252} It is also an antagonist of histamine H1, α1A-, α2B-, and α2C-adrenergic, and M3 muscarinic acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively).{24253} CPZ (10 mg/kg per day) increases latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and stereotypic movements in the open field test in rats.{43329} CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis induced by cisplatin (Item No. 13119) in dogs.{43330}  

 

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Description

An internal standard for the quantification of chlorpromazine by GC- or LC-MS

Formal name: 2-chloro-N,N-di(methyl-d3)-10H-phenothiazine-10-propanamine, monohydrochloride

Synonyms:  CPZ-d6

Molecular weight: 361.4

CAS: 1228182-46-4

Purity: ≥99% deuterated forms (d1-d6)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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